Almost  every guitar could benefit from having it setup properly. Even new guitars straight from the factory usually need to be adjusted. Most players after purchasing a new guitar want to customize it to there needs.   Older guitars need allot of attention too.
It never hurts to have a qualified repairman take a look at your instrument.  Guitars can usually always play better.
Setups include the following if applicable.
  Truss rod adjustment
  Nut adjustment
  Bridge and tailpiece adjustment
  Spring adjustment on tremolo
  Pickup adjustment
  Pickup pole piece adjustment
  Intonation
  Polishing Frets
  Clean and condition fingerboard
  Restring
  Oil tuners